Clopitab 75 MG Tablet 15

Common side effects of Clopitab 75mg tablet

• Diarrhoea: Diarrhoea is a commonly reported gastrointestinal side effect of Clopitab 75mg tablet. It is characterised by loose, watery stools occurring more frequently than usual. Some individuals may experience diarrhoea while taking Clopidogrel.
• Stomach Pain: The exact mechanism by which Clopidogrel causes stomach pain is not entirely understood, but it is believed to be related to its effects on the gastrointestinal system. Stomach pain or abdominal discomfort can occur as a side effect of the Clopitab 75mg tablet. Discomfort may manifest as general discomfort or a cramping sensation in the abdominal area.
• Indigestion or Heartburn (Dyspepsia): Indigestion(dyspepsia) and heartburn are common gastrointestinal side effects of Clopitab 75mg tablet. Heartburn can present as discomfort or a burning sensation in the upper abdomen, often followed by a sour taste in the mouth. 
• Bleeding: Bleeding is the most significant hematologic side effect of Clopitab 75mg tablet. Bleeding can manifest as nosebleeds, easy bruising, or bleeding that stops longer. Clopidogrel, an antiplatelet medication, can increase some individuals' bleeding risk. It inhibits platelet aggregation and reduces the ability of blood to clot, which can result in bleeding episodes.

Managing the Side Effects:

Here are some commonly suggested remedies to manage side effects:

• Diarrhoea: Diarrhoea can lead to dehydration, so drinking plenty of fluids to replace lost electrolytes and maintain hydration is essential. Opt for clear liquids such as water, broths, and herbal teas. Avoid caffeinated and sugary beverages as they may worsen symptoms.
• Stomach Pain: Stick to easily digestible foods that are gentle on the stomach. Choose plain rice, boiled potatoes, toast, bananas, vegetables, and lean proteins. Avoid spicy, greasy, or heavy foods that can exacerbate symptoms.
• Indigestion or Heartburn (Dyspepsia): Probiotics, beneficial bacteria, may help restore the natural balance of gut flora and alleviate symptoms of diarrhoea and indigestion. Consider consuming probiotic-rich foods such as yoghurt or taking over-the-counter probiotic supplements. Consult your healthcare professional for appropriate recommendations.
• Bleeding: Engaging in activities that may cause injury or trauma should be cautiously approached to minimise the risk of bleeding. This includes avoiding contact sports, heavy lifting, or any activity that puts you at risk of injury.

Precautions

Pregnancy

Limited data is accessible on the use of Clopitab 75mg tablet during pregnancy. Using Clopitab 75mg tablet without medical advice is not recommended as it may harm the developing foetus.

Breastfeeding

Clopitab 75mg tablet may pass into breast milk, and its effects on the nursing infant are not well-established. A healthcare professional can guide whether to continue breastfeeding or consider alternative treatment options.

Alcohol

Excessive alcohol consumption can raise the risk of gastrointestinal bleeding and other complications. It is recommended to consult with a doctor regarding alcohol consumption while taking Clopitab 75mg tablet.

Liver

Clopitab 75mg tablet is metabolised in the liver, and individuals with severe liver impairment may have an increased risk of bleeding. Close monitoring and appropriate dose adjustments are essential in such cases.

Kidney

Patients with kidney problems should use Clopitab 75mg tablet cautiously, and dosage adjustments may be necessary. Regular observation of kidney function may also be recommended.

Using Machine and Driving

Clopitab 75mg tablet is generally not associated with impairing the ability to operate machinery or drive a vehicle. Still, it is necessary to assess alertness and coordination due to potential individual variations.

Allergy

Individuals with known allergies or hypersensitivity to Clopidogrel or any other medication components should avoid using Clopitab 75mg tablet.

Use In Children

The safety and efficacy of Clopitab 75mg tablet in children have yet to be well established. Clopitab 75mg tablet is primarily indicated for use in adults and should not be used in children.

Use In Older Patients

Older patients (over 65 years) may be more susceptible to bleeding complications while using Clopitab 75mg tablet. Close monitoring and appropriate dose adjustments based on kidney function and overall health status may be necessary.

Interaction

Drug-Drug Interactions

Here are the categorised explanations of drug interactions with specific drugs:

• Warfarin: When taken with warfarin, an anticoagulant medication, Clopidogrel may raise the risk of bleeding.
• Aspirin: Combining Clopitab 75mg tablet with aspirin may increase the risk of bleeding.
• Rivaroxaban and Apixaban: Concurrent use of Clopitab 75mg tablet with rivaroxaban or apixaban, other antiplatelet or anticoagulant medications, may increase the risk of bleeding.
• Ibuprofen: Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), may raise the likelihood of bleeding when used with Clopitab 75mg tablet.
• Citalopram: Citalopram, an antidepressant, may increase the risk of bleeding when used with Clopitab 75mg tablet.
• Omeprazole: Omeprazole, a proton pump inhibitor, may reduce the effectiveness of Clopitab 75mg tablet by inhibiting its activation.

Drug-Food Interactions

Here are the categorised explanations of drug-food interactions:

Grapefruit and Grapefruit Juice:

Grapefruit and grapefruit juice can interfere with the breakdown of Clopitab 75mg tablet in the body, leading to increased drug levels and a potentially higher likelihood of adverse effects.

When taking a 75mg Clopitab tablet, avoiding consuming grapefruit or grapefruit juice is advised. Consult your doctor if you have any worries or inquiries.

Alcohol:

Alcohol can increase the risk of gastrointestinal bleeding when used with Clopitab 75mg tablet. It is advisable to reduce or avoid alcohol consumption while taking Clopitab 75mg tablet to reduce the risk of bleeding complications.

Drug-Disease Interactions

Some significant drug-disease interactions associated with Clopitab 75mg tablet:

Bleeding Disorders:

Clopitab 75mg tablet can increase the risk of bleeding. Individuals with bleeding disorders, such as haemophilia, a history of stroke or von Willebrand disease, may be at a higher risk of bleeding complications. 

Clopitab 75mg tablet should be used cautiously in individuals with bleeding disorders. Close monitoring by a healthcare provider is vital to assess the benefits and risks of treatment.

Liver Disease:

Clopitab 75mg tablet is metabolised in the liver. Severe liver disease can affect the breakdown and clearance of the medication.

Clopitab 75mg tablet should be used carefully in individuals with severe liver disease. Regular monitoring by a healthcare professional is essential, and dosage modifications may be required.

Kidney Disease:

Clopitab 75mg tablet is primarily excreted through the kidneys. Kidney disease can affect the elimination of the medication from the body.

Clopitab 75mg tablet should be used cautiously in individuals with kidney disease. It's crucial to have a healthcare professional closely watch you; dose modifications would be necessary.