Zentel 400 MG Tablet 1

The common side effects of Zentel are generally mild and transient and may include:

• Stomach pain: Stomach pain is a common side effect of the Zentel 400 mg tablet. It may be mild or severe due to stomach lining irritation. 
• Nausea: Nausea is a typical side effect of the Zentel 400 mg tablet. It may occur due to the medication irritating the stomach. 
• Vomiting: Vomiting may occur due to irritation of the stomach lining or the body's interaction with the medication.
• Headache: Headache may occur due to the medication's effect on the central nervous system or the body's response. 
• Dizziness: Dizziness is a less common side effect of the Zentel 400 mg tablet. It may occur due to the medication's effect on the central nervous system or the body's reaction. 

Managing the Side Effects

Here are some general suggestions for managing the common side effects of Zentel 400 mg tablet:

Stomach pain

• Avoid consuming spicy, fatty or fried foods, as they aggravate stomach pain.
• Try drinking ginger tea or supplements, as ginger has anti-inflammatory properties that may help reduce stomach pain.

Nausea and vomiting

• Drink water or ginger ale in small amounts throughout the day to stay hydrated.
• Eat small, frequent meals instead of large meals.
• Try eating bland foods, such as crackers or plain rice.
• Avoid foods that are greasy, spicy, or fatty.

Headache

• Apply a cool compress to your forehead or temples to help reduce headache.
• Try practising relaxation techniques, such as deep breathing or meditation, to help reduce stress and tension.
• Avoid exposure to bright lights or loud noises that may exacerbate headache pain.

Dizziness

• Avoid standing up too quickly from a seated or lying position, which can trigger dizziness.
• Avoid driving or operating heavy machinery if you feel dizzy since this might be risky. Drink plenty of water the whole day to stay hydrated.

Precautions

Pregnancy

Zentel 400 mg tablet is not recommended during pregnancy, especially during the first trimester. It may harm the developing fetus.

Breastfeeding

Zentel 400 mg tablet may pass into breast milk, harming a nursing baby. It is recommended to avoid breastfeeding while using Zentel 400 mg tablet. 

Alcohol

It is advisable to avoid alcohol during the Zentel 400 mg tablet treatment as it may raise the risk of liver damage.

Liver

When using Zentel 400 mg tablets, patients with liver issues or a history of liver illness should proceed with precaution. The medicine is metabolised in the liver, and if the liver is not working correctly, the drug may build up in the body and be harmful.

Kidney

Patients with kidney problems should be careful when using the Zentel 400 mg tablet. The drug is removed from the body through the urine; if the kidneys aren't working correctly, the drug can accumulate in the body and cause injury.

Using Machine and Driving

Zentel 400 mg tablet side effects that may make driving or operating machinery difficult include headache, dizziness, and other neurological adverse effects. Patients should refrain from engaging in such activities until they can safely do so.

Allergy

Patients with a known allergy to albendazole or any other ingredient in Zentel 400 mg tablet should avoid using it. Allergic reactions may be from mild to severe and, in some cases, life-threatening.

Use In Children

Zentel 400 mg tablet should only be used in children (over the age of 6 years) and teenagers if prescribed by a doctor. It is not suggested for usage in children under the age of six. As a result, get guidance from your doctor.

Use In Older Patients

Zentel 400 mg tablet should be taken cautiously in older people (those over 65). Consult your doctor before taking it

Interaction

Drug-Drug Interactions

Some of the essential drug-drug interactions of Zentel 400 mg tablet are

• Anthelmintic: When taken simultaneously with praziquantel, an anthelmintic drug, there is an increased risk of liver toxicity. Therefore, the simultaneous use of these drugs should be avoided or monitored closely.
• Corticosteroid: The simultaneous use of corticosteroids, such as dexamethasone and albendazole, may increase the risk of central nervous system toxicity, like seizures. Therefore, the use of these drugs together should be avoided, or their use should be monitored closely.
• Antacid: Simultaneous use of cimetidine, an antacid, with albendazole may reduce albendazole absorptione. Therefore, it is recommended to separate the administration of these drugs by at least two hours.
• Anti-asthma: The simultaneous use of theophylline, an anti-asthma drug, and albendazole may increase the serum levels of theophylline, leading to toxicity. Therefore, the use of these drugs together should be avoided, or their use should be monitored closely.

Drug-Food Interactions

The drug-food interactions with Zentel 400 mg tablet - 

• For maximum efficiency, albendazole should always be taken with food. 
• Grapefruit juice with albendazole, increases the level of albendazole which causes side effects like headache, nausea, and dizziness.
• Consume Zentel 400 mg tablets with a high-fat meal. Absorption is enhanced by a high-fat diet. When treating systemic infections, take with food.

Drug-Disease Interactions:

Here are the drug-disease interactions to consider:

• Myelosuppression: Zentel 400 mg tablet may cause bone marrow suppression, leading to decreased blood cell production. Regular monitoring of blood counts is recommended. Patients with a history of blood disorders, such as anaemia, leukopenia, or thrombocytopenia, should use the Zentel 400 mg tablet cautiously.
• Hepatobiliary dysfunction: Patients with liver and biliary diseases should use Zentel 400 mg tablet cautiously as it may worsen their condition. Zentel is metabolised in the liver, and its use may raise the possibility of liver damage or liver function abnormalities. Patients with liver diseases, such as hepatitis or cirrhosis, should be monitored closely while taking Zentel 400 mg tablet.
• Neurological disorder: Zentel 400 mg tablet may cause neurological side effects like headache, dizziness, and seizures. Close monitoring is recommended to ensure that any neurological symptoms are promptly identified and treated. Patients with a history of neurological disorders, such as epilepsy or seizures, should use Zentel 400 mg tablet carefully.
• Kidney dysfunction: Zentel 400 mg tablet is eliminated from the body through the kidneys. Patients with kidney dysfunction or renal impairment may have a slower drug elimination, leading to an increased risk of adverse effects. While taking Zentel 400 mg tablet, patients with kidney disorders should be closely observed.