Istamet 50mg/500mg Tablet 15

Sun Pharma Laboratories Ltd.

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Composition

Metformin (500 Mg) + Sitagliptin (50 Mg)

Istamet Tablet is used to control high blood sugar levels in people with type 2 diabetes. It helps manage blood sugar, prevent complications such as kidney damage, blindness, and heart disease, and supports healthy insulin function without causing weight gain.

Beyond its main application, this medicine aids in maintaining a healthy blood sugar balance, especially when supplemented by an appropriate diet and regular physical activity. It can be prescribed alone or with other diabetes medications, depending on your personal health condition and treatment needs.

Before starting this medicine, it's crucial to consult your doctor who will determine the correct dosage for you. You should inform your doctor about any pre-existing conditions or ongoing medicines you're taking. If you experience any side effects while on this medicine, report them to your doctor without delay. Remember to continue taking the medicine for the duration prescribed by your doctor for optimal results.

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Istamet Tablet is used to control blood sugar levels in type 2 diabetes. It combines Sitagliptin and Metformin, which help improve insulin sensitivity and reduce glucose production.

Directions for Use of Istamet 50mg/500mg Tablet 15

Here's how you should take Istamet 50mg/500mg Tablet:

Follow and complete the course prescribed by your doctor.
Keep up with the recommended diet while taking this medicine.
If you have any questions, consult your doctor.

Istamet 50mg/500mg Tablet is taken orally.

Side Effects of Istamet 50mg/500mg Tablet 15

Common side effects of Istamet 50mg/500mg Tablet may include nausea, vomiting, diarrhea, abdominal bloating, decreased appetite, upper respiratory tract infection, and hypoglycemia.

Managing the Side Effects:

Most side effects are temporary and generally harmless and resolve upon discontinuing the use of Istamet 50mg/500mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some guidelines to manage a couple of common side effects:

Diarrhoea: Try taking Istamet 50mg/500mg Tablet with meals to minimise this effect.
Hypoglycemia: Ensure to maintain regular meal times while on this medication to prevent low blood glucose levels.

Istamet 50mg/500mg Tablet contains two active ingredients:

Sitagliptin (50 mg): This component belongs to a category of medicines known as DPP-4 inhibitors. It works by increasing levels of certain hormones in your body known as incretins. These hormones stimulate your pancreas to produce more insulin when your blood sugar level is high, and simultaneously reduce the production of glucagon, a hormone that raises blood sugar.
Metformin (500 mg): Known as a biguanide, metformin reduces glucose production in your liver and decreases the absorption of glucose from your intestines. It also helps improve the sensitivity of your body's tissues to insulin.

Together, the actions of these components help lower and maintain blood sugar levels within a normal range.

Pregnancy

Caution is advised while taking Istamet 50mg/500mg Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you are breastfeeding, it's important to discuss with your doctor before starting Istamet 50mg/500mg Tablet.

Alcohol

Drinking alcohol should be limited or avoided while taking Istamet 50mg/500mg Tablet, as it may increase the risk of lactic acidosis and hypoglycaemia.

Liver

If you have any liver problems, caution is advised while taking Istamet 50mg/500mg Tablet. It's essential to discuss these concerns with your doctor before starting this medicine.

Kidney

Istamet 50mg/500mg Tablet is not recommended for patients with severe kidney disease. Regular monitoring of kidney function is advisable while taking this medicine.

Using Machines & Driving

Istamet 50mg/500mg Tablet may affect your ability to drive or operate machinery. If you feel unwell or less alert, avoid such activities and speak to your doctor.

Allergy

It's crucial to inform your doctor if you are allergic to sitagliptin, metformin, or any other components of Istamet 50mg/500mg Tablet.

Children

Istamet 50mg/500mg Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Istamet 50mg/500mg Tablet under medical supervision, as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age.

Interactions of Istamet 50mg/500mg Tablet 15

Drug-Drug Interactions

Istamet 50mg/500mg Tablet interacts with the following medicines:

Cationic Medications: Medicines like amiloride and trimethoprim may interact with Istamet, affecting how well it works.
Diuretics: These can interact with Istamet, potentially altering its effectiveness in controlling blood sugar levels.
Corticosteroids: Medicines like prednisolone can increase blood sugar levels, reducing the effectiveness of Istamet.
Thyroid Medications: Medicines such as levothyroxine may interact with Istamet, affecting blood sugar control.
Oral Contraceptives: These medicines could potentially interact with Istamet, altering its effectiveness.

Drug-Food Interactions

Certain foods may affect how Istamet 50mg/500mg Tablet works. It's advisable to follow the diet prescribed by your doctor while taking this medicine.

Drug-Disease Interactions

Istamet 50mg/500mg Tablet interacts with the following diseases:

Severe Kidney Disease: The metformin in Istamet could potentially worsen this condition.
Type 1 Diabetes: Istamet is not indicated for use in patients with type 1 diabetes.
Diabetic Ketoacidosis: Patients with this condition should not take Istamet as it could exacerbate their symptoms.

Daily Dose

Your doctor will decide the daily dose of Istamet 50mg/500mg Tablet based on your specific needs. This will depend on factors such as your condition's severity and your response to the medicine. It's crucial to follow the prescribed dosage, and never increase it without consulting your doctor.

Over Dose

An overdose of Istamet 50mg/500mg Tablet may lead to some overdose effects like nausea, vomiting, and bloating. If you accidentally take more than the prescribed dose, don't panic, but do inform your doctor.

Missed Dose

If you forget to take your regular dose of Istamet 50mg/500mg Tablet, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and stick to your usual dosage schedule. Always consult your doctor before making any changes to your medicine schedule.

Store Istamet 50mg/500mg Tablet at room temperature, ideally between 15 to 30°C.
Keep it away from direct sunlight and damp areas. So, avoid places like your bathroom or kitchen windowsill.
Ensure it's out of sight and reach of children.
Always check the expiry date before use and don't use the medicine if it's expired.

Adopt a balanced diet that's low in sugar and high in fibre to help manage your blood sugar levels while on Istamet 50mg/500mg Tablet.
Regular physical exercise, such as walking or cycling, can improve your body's insulin sensitivity and thus help control your blood sugar. Always consult your doctor before starting any new exercise regimen.

Fact Box

Drug Category	DPP-4 inhibitor, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What is Istamet 50mg/500mg Tablet used for?

Istamet 50mg/500mg Tablet is used to manage type 2 diabetes by helping control blood sugar levels. It combines metformin (which improves insulin sensitivity) and sitagliptin (which helps regulate blood sugar levels).

How does Istamet 50mg/500mg Tablet work?

This medicine combines sitagliptin and metformin to increase insulin production, decrease glucose production in the liver, and improve insulin sensitivity.

What should I do if I miss a dose of Istamet 50mg/500mg Tablet?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one.

Can Istamet 50mg/500mg Tablet cause Vitamin B12 deficiency?

Long-term use of metformin, one component of Istamet, may lead to Vitamin B12 deficiency. Regular monitoring is advised.

Is it safe to drink alcohol while taking Istamet 50mg/500mg Tablet?

Avoid or limit alcohol consumption when taking this medicine as it could increase the risk of lactic acidosis and hypoglycaemia.

Are there any precautions I need to take while using Istamet 50mg/500mg Tablet?

Inform your doctor about your complete medical history and any other medications you are currently taking. Regular monitoring of kidney function is recommended.

Can other medications interact with Istamet 50mg/500mg Tablet?

Yes. Certain medications can interact with this tablet. Always inform your doctor about all medicines you are taking to avoid potential interactions.

Last Updated On 13 Feb. 2025 | 7:35PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

References

MedlinePlus. (n.d.). Metformin. U.S. National Library of Medicine. Retrieved April 1, 2024, from https://medlineplus.gov/druginfo/meds/a696005.html
MedlinePlus. (n.d.). Sitagliptin. U.S. National Library of Medicine. Retrieved April 1, 2024, from https://medlineplus.gov/druginfo/meds/a606023.html
Merck Sharp & Dohme Corp. (2007). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022044s042lbl.pdf
Sitagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01261
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331

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