Vymada 50mg Tablet 14

Novartis India Ltd

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Vymada 50 Tablet is used to treat chronic heart failure. It helps improve heart function, reduces the risk of hospitalization, and lowers the chances of death in patients with weakened hearts. It is typically used alongside other heart failure medications for better management of the condition.

In addition to its main use, this medicine also helps to improve symptoms of heart failure such as breathlessness, fatigue, and oedema. It enhances exercise tolerance and quality of life for patients who find other standard treatments for heart failure ineffective.

Before starting this medication, consult your doctor for the appropriate dosage and frequency. It's important to inform your doctor about any ongoing medications or pre-existing conditions you have. If you observe any side effects while taking this medicine, let your doctor know promptly. Continue taking it for the duration prescribed by your doctor for the best results.

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Vymada 50mg Tablet is used to treat high blood pressure (hypertension) and help manage chronic heart failure with reduced ejection fraction. It improves heart failure symptoms, enhances exercise capacity, and boosts overall quality of life in heart failure patients.

Directions for Use of Vymada 50mg Tablet 14

To use Vymada 50mg Tablet properly, follow these steps:

Swallow the tablet whole with water. Avoid crushing, chewing, or dividing the tablet.
Stick to the exact dose and timing as directed by your doctor.
Never change the dosage or stop taking this medicine without consulting your doctor.

Vymada 50mg Tablet is taken orally.

Common side effects of Vymada 50mg Tablet includes low blood pressure, high potassium levels, kidney problems, cough, headache, and nausea.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Vymada 50mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypotension: To manage this condition, avoid sudden changes in your posture and get up slowly from sitting or lying down positions.
Hyperkalemia: Monitor your intake of foods rich in potassium to help manage this condition.

This medicine is a combination of two active ingredients:

Sacubitril (24 mg): This ingredient inhibits an enzyme known as neprilysin. Neprilysin is responsible for breaking down chemicals called natriuretic peptides, which are beneficial for your body. By preventing their breakdown, sacubitril boosts their effects, leading to increased sodium and water removal from your body, a widening of blood vessels, and reduced changes in the structure and function of the heart.
Valsartan (26 mg): It helps treat high blood pressure and heart problems. It belongs to a group of medicines called angiotensin receptor blockers. Valsartan works by relaxing blood vessels, making it easier for blood to flow smoothly. This helps lower blood pressure and reduces the risk of heart attacks and strokes.

Pregnancy

Vymada 50mg Tablet is contraindicated if you are pregnant. If you are planning to become pregnant, consult your doctor before starting this medication.

Breastfeeding

Taking Vymada 50mg Tablet is not recommended while nursing. Consult your doctor before taking this medicine if you are breastfeeding.

Alcohol

While taking Vymada 50mg Tablet, it's best to limit or avoid alcohol consumption as it may lead to increased dizziness or fainting.

Liver

Caution is advised if you have liver problems. Vymada 50mg Tablet may affect liver function and is not recommended for severe liver diseases. Consult your doctor before starting this medicine.

Kidney

If you have a history of kidney issues, it's advised that you consult your doctor before taking Vymada 50mg Tablet. Regular monitoring of kidney function is recommended during its use.

Using Machines & Driving

This medicine may cause dizziness, which could affect your ability to drive or operate machinery. Avoid these activities if you experience these side effects.

Allergy

This medicine is contraindicated for individuals who have had allergic reactions to sacubitril, valsartan, or any other components of the formulation.

Children

Caution is advised while giving Vymada 50mg Tablet to those under 18 years of age. Consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take this medicine under medical supervision due to potential side effects. Caution is advised particularly if patients are above 70 years old due to possible liver and kidney issues.

Drug-Drug Interactions

Vymada 50mg Tablet interacts with the following medicines:

Antihypertensive medicines: ACE inhibitors used to lower high blood pressure, like enalapril, or lisinopril, may interact with this tablet, possibly increasing the risk of angioedema.
Renin inhibitors: Medicines like aliskiren can exacerbate renal issues when taken by diabetic patients along with Vymada 50mg Tablet.
Potassium-sparing diuretics and potassium supplements: When taken with Vymada 50mg Tablet, medicines like amiloride and eplerenone can lead to high potassium levels in your blood (hyperkalaemia).
Non-steroidal anti-inflammatory drugs (NSAIDs): When taken with this tablet, medicines like ibuprofen and naproxen can cause a decline in kidney function and increase serum potassium.

Drug-Food Interactions

Vymada 50mg Tablet may interact with the following foods:

High-potassium foods: Consuming these while on this tablet might increase your blood potassium levels.

Drug-Disease Interactions

Vymada 50mg Tablet interacts with the following diseases:

Kidney disease: If you have kidney disease, consuming this tablet might exacerbate your condition.
Liver disease: People with liver disease need to be careful as this medicine could worsen their condition.
Diabetes: The medicine could impact blood sugar control, making it crucial to monitor glucose levels closely.
High blood potassium levels: This tablet might increase the potassium levels in your body.

Daily Dose

The daily dose of Vymada 50mg Tablet should be taken as advised by your doctor. The dosage might vary due to individual factors such as your health condition and how you respond to the medicine. It's crucial to follow the prescribed dosage and not to alter it without consulting your doctor.

Over Dose

If you consume more Vymada 50mg Tablet than recommended, you might feel light-headed or experience a faster heartbeat. If these symptoms persist or worsen, inform your doctor promptly.

Missed Dose

In case you forget to take your regular dose of this medicine, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and continue with your usual dosage schedule. Never increase your dosage without consulting your doctor.

Store your Vymada 50mg Tablet below 30°C in a cool, dry place.
Keep it away from direct sunlight and moisture.
Keep the medicine out of reach of children.
Use the tablet before its expiry date.

Limit your intake of foods high in potassium, like bananas and spinach. This can help manage hyperkalemia, a possible side effect of Vymada 50mg Tablet.
Maintain a low-sodium diet to support the medicine's role in managing heart failure. Avoid salty snacks and opt for fresh foods over processed ones.

Fact Box

Drug Category	Neprilysin Inhibitor, ARB
Therapeutic Category	Heart Failure Medicine
Available Dosage Types	No
Habit Forming	No
Ailment	Chronic Heart Failure, Reduced Ejection Fraction

What is the main use of Vymada 50mg Tablet?

Vymada 50mg Tablet is used to manage chronic heart failure in adults, particularly where ejection fraction is reduced.

How does Vymada 50mg Tablet work in the body?

It contains sacubitril and valsartan that work together to relax blood vessels and improve blood flow.

How should I take Vymada 50mg Tablet?

You can take it with or without food, ideally at the same time each day. Always follow your doctor's dosage instructions.

What if I miss a Vymada 50mg Tablet dose?

Take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed one.

Are there any side effects of Vymada 50mg Tablet?

Yes, common side effects include low blood pressure, increased blood potassium levels, and renal impairment. Consult your doctor if they persist.

Who should avoid taking Vymada 50mg Tablet?

Those with hypersensitivity to its ingredients, severe liver impairment, pregnant women, and those on certain medications should avoid it.

Can Vymada 50mg Tablet be used in patients with preserved ejection fraction heart failure?

No, Vymada 50mg Tablet is specifically indicated for heart failure with reduced ejection fraction.

Last Updated On 21 Feb. 2025 | 11:46AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Osama Ahmed

Dental/Medical Writer, Editor, Reviewer | 3 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

The Inspire BKC Part 601 & 701 Bandra Kurla Complex Bandra(E) Mumbai - India

Country of origin: ITALY

References

U.S. Food and Drug Administration. (2021, Feb). ENTRESTO® (sacubitril and valsartan) tablets label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021283s033lbl.pdf
U.S. Food and Drug Administration. (2011, Dec). Diovan (valsartan) tablets label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021283s033lbl.pdf
Nicolas, D., Kerndt, C. C., & Reed, M. (2022). Sacubitril-Valsartan. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK507904/
Kaplinsky E. (2016). Sacubitril/valsartan in heart failure: latest evidence and place in therapy. Therapeutic advances in chronic disease, 7(6), 278–290. https://doi.org/10.1177/2040622316665350
Black, H. R., Bailey, J., Zappe, D., & Samuel, R. (2009). Valsartan: more than a decade of experience. Drugs, 69(17), 2393–2414. https://doi.org/10.2165/11319460-000000000-00000
DrugBank Online. (2024, May 5). Valsartan. https://go.drugbank.com/drugs/DB00177
DrugBank Online. (2022, Mar 24). Sacubitril. https://go.drugbank.com/drugs/DB09292

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